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  • 方淯靖

    职务:
    职称:副研究员
    专长:
    副研究员

    方淯靖,副研究员,2006年毕业于香港中文大学医学院,获得博士学位,师承Brian Tomlinson 教授。期间参与了数个临床试验课题,其中包括香港研究基金委员会资助课题(4905/00M)“高血压遗传基因的研究”,主要负责基因芯片的设计和制作、数据分析等。同时还参与了国家自然基金资助课题 “复杂性状基因定位数据连锁分析方法的研究”,主要负责实验室部分(基因芯片的设计、制作、验证等)。在攻读学位期间主要利用先进的基因芯片技术,在众多的候选基因中,检测到数个与香港的汉族人种高血压病的发生具有高度连锁关系的疾病基因的单核苷酸多态性(SNP)  

    2006年加入中山大学肿瘤防治中心结直肠科,在万德森教授和潘志忠教授的指导下,主要从事大肠癌的研究,期间主持了国家自然科学基金项目(靶向雌激素受体beta对结肠癌肝转移的影响、机制和临床意义)、教育部博士点基金项目(三苯氧胺靶向雌激素受体beta亚型对于个体化治疗结肠癌肝转移的影响及意义)和广东省医学科研基金项目(结直肠癌肝转移抗雌激素治疗的机制及其潜在临床意义)。并参与多项国家级和省部级课题,其中包括863项目、国家自然科学基金项目,广东省和广州市科技计划项目等。主编了《社区肿瘤防治丛书》分册《环境与癌症》,由广东科技出版社在2009年出版发行。

    主要研究方向:1.大肠癌内分泌治疗的基础研究;2. 大肠癌肝转移研究;3. 大肠癌分子分期研究;4. 华南地区大肠癌患者生命质量检测。

    近年发表的主要论文有:

    1.        Yu-Jing Fang, Xiao-Jun Wu, Qian Zhao, Li-Ren Li, Zhen-Hai Lu, Pei-Rong Ding, Rong-Xin Zhang, Ling-Heng Kong, Fu-Long Wang, Jun-Zhong Lin, Gong Chen, Zhi-Zhong Pan, De-SenWan. Hospital-based colorectal cancer survival trend of different tumor locations from 1960s to 2000s. 2013. Plos One. 8(9):e73528.

    2.        P Li, Y J Fang, F Li, Q J Ou, G Chen, and G Ma. ERCC1, defective mismatch repair status as predictive biomarkers of survival for stage III colon cancer patients receiving oxaliplatin-based adjuvant chemotherapy. 2013. British Journal of Cancer. 108:1238-1244.

    3.        Wu Jiang, Yu-Jing Fang, Xiao-Jun Wu, Fu-Long Wang, Zhen-Hai Lu, Rong-Xin Zhang, Pei-Rong Ding, Wen-Hua Fan, Zhi-Zhong Pan, De-Sen Wan. Intraoperative blood loss independently predicts survival and recurrence after resection of colorectal cancer liver metastasis. 2013. Plos One. 8(10):e76125. (co-first author)

    4.        Xiao Zhong, Yu-Jing Fang, Zhi-Zhong Pan, Bin Li, Lian Wang, Mei-Chun Zheng, Yu-Ming Chen and Cai-Xia Zhang. Dietary fat, fatty acid intakes and colorectal cancer risk in Chinese adults: a case-control study. 2013. Eur J Cancer Prev. 22(5):438-447.

    5.        Yu-Jing Fang, Guo-Qiang Wang, Zhen-Hai Lu, Lin Zhang, Ji-Bin Li, Xiao-Jun Wu, Pei-Rong Ding, Qing-Jian Ou, Mei-Fang Zhang, Wu Jiang, Zhi-Zhong Pan, De-Sen Wan. Different effects of ERβ and TROP2 expression in Chinese patients with early-stage colon cancer. 2012. Tumor Biology. 33(6):2227-2235.

    6.        Yu-Jing Fang, Lin Zhang, Xiao-Jun Wu, Zhen-Hai Lu, Ji-Bin Li, Qing-Jian Ou, Mei-Fang Zhang, Pei-Rong Ding, Zhi-Zhong Pan, De-Sen Wan. Impact of ERb and CD44 Expression on the Prognosis of Patients with Stage II colon cancer. 2012. Tumor Biology. 33(6):1907-1914.

    7.        Guo, Youling, Tomlinson, Brian, Chu, Tanya, Fang, Yu-Jing, Gui, Hongsheng, Tang, Clara S., Yip, Benjamin H., Cherny, Stacey S., Hur, Yoon-Mi, Sham, Pak Chung, Lam, Tai Hing, Thomas, Neil G. A Genome-Wide Linkage and Association Scan Reveals Novel Loci for Hypertension and Blood Pressure Traits. 2012. Plos One. 7(2): e31489

    8.        Wu, X.J., Fang, Y.J., Lin, J.Z., Lu, Z.H., Li, L.R., Chen, G., Ding, P.R., Kong, L.H., Pan, Z.Z., Wan, D.S. Circulating Antibodies to Carcinoembryonic Antigen Related to Improved Recurrence-free Survival of Patients with Colorectal Carcinoma. 2011. Journal of International Medical Research.   39(3): 838-845. (co-first author)

    9.        Ding, Pei-Rong, An, Xin, Zhang, Rong-Xin, Fang, Yu-Jing, Li, Li-Ren, Chen, Gong, Wu, Xiao-Jun, Lu, Zhen-Hai, Lin, Jun-Zhong, Kong, Ling-Heng, Wan, De-Sen, Pan, Zhi-Zhong. Elevated preoperative neutrophil to lymphocyte ratio predicts risk of recurrence following curative resection for stage IIA colon cancer. 2010. International Journal of Colorectal Disease. 25(12): 1427-1433.

    10.    Fang, Yu-Jing, Lu, Zhen-Hai, Wang, Fang, Wu, Xiao-Jun, Li, Li-Ren, Zhang, Li-Yi, Pan, Zhi-Zhong, Wan, De-Sen. Prognostic impact of ER beta and MMP7 expression on overall survival in colon cancer. 2010. Tumor Biology. 31(6): 651-658.

    11.    Li, Li-Ren, Fang, Yu-Jing, Pan, Zhi-Zhong, Wu, Xiao-Jun, Wan, De-Sen. Hardingham, JE (Hardingham, Jennifer E.)1; Rieger, N (Rieger, Nicholas). Length of lymphangiogenesis in the rectal tissues distal to rectal cancer. 2010. Tumor Biology. 31(6): 667-671.

    12.     Fang, Yu-Jing, Deng, Han-Bing, Thomas, G. Neil, Tzang, Chi H., Li, Cai-Xia, Xu, Zong-Li, Yang, Mengsu, Tomlinson, Brian. Linkage of angiotensinogen gene polymorphisms with hypertension in a sibling study of Hong Kong Chinese. 2010. Journal of Hypertension. 28(6): 1203-1209.  

    13.    Fang, Yu-Jing, Pan, Zhi-Zhong, Li, Li-Ren, Lu, Zhen-Hai, Zhang, Li-Yi, Wan, De-Sen. MMP7 expression regulated by endocrine therapy in ER beta-positive colon cancer cells. 2009. Journal of Experimental & Clinical Cancer Research. 28: 132.

    14.    Fang, Y. J., Lu, Z. H., Wang, G. Q., Pan, Z. Z., Zhou, Z. W., Yun, J. P., Zhang, M. F., Wan, D. S. Elevated expressions of MMP7, TROP2, and survivin are associated with survival, disease recurrence, and liver metastasis of colon cancer. 2009. International Journal of Colorectal Disease. 24(8): 875-884.

    15.    Fang Y.J., Thomas, G.N., Xu, Z.L., Fang, J.Q., Critchley, A.J.H., Tomlinson, B. An affected pedigree member analysis of linkage between the dopamine D2 receptor gene TaqI polymorphism and obesity and hypertension. 2005. International Journal of Cardiology. 102(1): 111-116.

    16.    Yu-Jing Fang, Benny SP Fok, Brian Tomlinson. Etoricoxib – a new highly selective COX-2 inhibitor. Medical Progress 2003; 30(11): 33-39.

     

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