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  • 李焱

    职务:
    职称:博士,研究员, 博士生导师
    专长:从事肿瘤的发病机制和防治研究
      李焱,博士,研究员, 博士生导师( 肿瘤学), 中山大学肿瘤防治中心, 华南肿瘤学国家重点实验室工作,从事肿瘤的发病机制和防治研究。主持多项基金包括:国家自然科学基金(81672357,81472255,81172338和30700820),广东省自然科学基金,广东省科技计划等。并参与多项科研项目如973、863和国家科技重大专项等研究。作为参与者获得了高等学校自然科学奖一等奖,广东省科学技术奖一等奖等。在国际知名杂志如Gastroenterology, Cancer Res等发表第一或通讯作者文章多篇。是World Journal of Gastroenterology和The New American Journal of Gastroenterology &Hepatology的编委会成员和Plos One, Chinese Journal of Cancer,Cancer Medicine等杂志的审稿人。

    教育背景和工作经历:

      1996.9-2001.7:中山医科大学 博士研究生
      2004.4-2005.12:美国耶鲁大学医学院 博士后

    近年来主要代表作:(*通讯作者)
      1. Li Y*, Fu L, Li JB, Qin Y, Zeng TT, Zhou J, Zeng ZL, Chen J, Cao TT, Ban X, Qian C, Cai Z, Xie D, Huang P, Guan XY*. Increased Expression of EIF5A2, via Hypoxia or Gene Amplification, Contributes to Metastasis and Angiogenesis of Esophageal Squamous Cell Carcinoma. Gastroenterology. 2014 Jun;146(7):1701-1713.
      2. Li Y, Chen L, Nie CJ, Zeng TT, Liu H, Mao X, Qin Y, Zhu YH, Fu L, Guan XY. Downregulation of RBMS3 is associated with poor prognosis in esophageal squamous cell carcinoma. Cancer Res. 2011 Oct 1; 71(19):6106-15. 
      3. Li Y, Nie CJ, Hu L, Qin YR, Liu HB, Zeng TT, Chen LL, Fu L, Deng W, Chen SP, Jia WH, Zhang CY, Xie D, Guan XY.  Characterization of a novel mechanism of genomic instability involving SEI1/SET/NM23H1 pathway in esophageal cancers.  Cancer Res. 2010Jul 15.70(14):5695-705.
      4. Huang PY, Zeng TT, Ban X, Li MQ, Zhang BZ, Zhu YH, Hua WF, Mai HQ, Zhang L, Guan XY*, Li Y*. Expression of EIF5A2 associates with poor survival of nasopharyngeal carcinoma patients treated with induction chemotherapy. BMC Cancer. 2016 Aug 22;16:669. doi: 10.1186/s12885-016-2714-2.
      5. Yang H, Li XD, Zhou Y, Ban X, Zeng TT, Li L, Zhang BZ, Yun J, Xie D, Guan XY, Li Y*. Stemness and chemotherapeutic drug resistance induced by EIF5A2 overexpression in esophageal squamous cell carcinoma. Oncotarget. 2015 Sep 22;6(28):26079-89.
      6. Li H, Zhang J, Chen SW, Liu LL, Li L, Gao F, Zhuang SM, Wang LP, Li Y*, Song M*. Cancer-associated fibroblasts provide a suitable microenvironment for tumor development and progression in oral tongue squamous cancer. J Transl Med. 2015 Jun 21;13(1):198.
      7. Song Y, Li J, Zhu Y, Dai Y, Zeng T, Liu L, Li J, Wang H, Qin Y, Zeng M, Guan XY*, Li Y*. MicroRNA-9 promotes tumor metastasis via repressing E-cadherin in esophageal squamous cell carcinoma. Oncotarget. 2014 Nov 30;5(22):11669-80.
      8. Huang PY, Zeng TT, Li MQ, Ban X, Zhu YH, Zhang BZ, Mai HQ, Zhang L, Guan XY*, Li Y*. Proteomic analysis of a nasopharyngeal carcinoma cell line and a nasopharyngeal epithelial cell line. Tumori. 2015 Nov 14;101(6):676-83. 
      9. Huang PY, Li Y, Luo DH, Hou X, Zeng TT, Li MQ, Mai HQ, Zhang L. Expression of Aurora-B and FOXM1 predict poor survival in patients with nasopharyngeal carcinoma. StrahlentherOnkol. 2015 Aug;191(8):649-55.  (SCI 2.898)
      10. Li Y*, Zhu CL, Nie CJ, Li JC, Zeng TT, Zhou J, Chen J, Chen K, Fu L, Liu H, Qin Y, Guan XY*.  Investigation of Tumor Suppressing Function of CACNA2D3 in Esophageal Squamous Cell Carcinoma. PLoS One. 2013;8(4):e60027. 
      11. Huang PY, Li Y, Mai HQ, Luo RZ, Cai YC, Zhang L. Expression of ERCC1 predicts clinical outcome in locoregionally advanced nasopharyngeal carcinoma treated with cisplatin-based induction chemotherapy.OralOncol. 2012 Oct;48(10):964-8. (SCI 3.607) (Co-first)
      12. Li Y*, Guan XY*. EIF5A2 promotes tumor metastasis and angiogenesis.  ScienceProceedings  2014;1:e381.
      13. Li Y, Shao JY, Liu RY, Zhou L, Chai LP, Li HL, Han HY, Huang BJ, Zeng MS, Zhu XF, Liu Q, Fu LW, Huang W. Evaluation of long-term toxicity of Ad/hIFN-, an Adenoviral vector encoding the human interferon-gamma gene, in nonhuman primates. Hum Gene Ther. 2008 Aug;19(8):827-39.
      14. Chen K, Li Y*, Dai Y, Li J, Qin Y, Zhu Y, Zeng T, Ban X, Fu L, Guan XY*. Characterization of Tumor Suppressive Function of cornulin in Esophageal Squamous Cell Carcinoma. PLoS One. 2013 Jul 24;8(7):e68838. doi: 10.1371/journal.pone.0068838. 
      15. Xue G, Liu RY, Li Y, Cheng Y, Liang ZH, Wu JX, Zeng MS, Tian FZ, Huang W. Dendritic cells modified with 6Ckine/IFNgamma fusion gene induce specific cytotoxic T lymphocytes in vitro. Cancer ImmunolImmunother. 2007 Nov;56(11):1831-43. (Co-first author)

    联系方式:liyan@sysucc.org.cn or liy6@mail.sysu.edu.cn

      李焱,博士,研究员, 博士生导师( 肿瘤学), 中山大学肿瘤防治中心, 华南肿瘤学国家重点实验室工作,从事肿瘤的发病机制和防治研究。主持多项基金包括:国家自然科学基金(81672357,81472255,81172338和30700820),广东省自然科学基金,广东省科技计划等。并参与多项科研项目如973、863和国家科技重大专项等研究。作为参与者获得了高等学校自然科学奖一等奖,广东省科学技术奖一等奖等。在国际知名杂志如Gastroenterology, Cancer Res等发表第一或通讯作者文章多篇。是World Journal of Gastroenterology和The New American Journal of Gastroenterology &Hepatology的编委会成员和Plos One, Chinese Journal of Cancer,Cancer Medicine等杂志的审稿人。

    教育背景和工作经历:

      1996.9-2001.7:中山医科大学 博士研究生
      2004.4-2005.12:美国耶鲁大学医学院 博士后

    近年来主要代表作:(*通讯作者)
      1. Li Y*, Fu L, Li JB, Qin Y, Zeng TT, Zhou J, Zeng ZL, Chen J, Cao TT, Ban X, Qian C, Cai Z, Xie D, Huang P, Guan XY*. Increased Expression of EIF5A2, via Hypoxia or Gene Amplification, Contributes to Metastasis and Angiogenesis of Esophageal Squamous Cell Carcinoma. Gastroenterology. 2014 Jun;146(7):1701-1713.
      2. Li Y, Chen L, Nie CJ, Zeng TT, Liu H, Mao X, Qin Y, Zhu YH, Fu L, Guan XY. Downregulation of RBMS3 is associated with poor prognosis in esophageal squamous cell carcinoma. Cancer Res. 2011 Oct 1; 71(19):6106-15. 
      3. Li Y, Nie CJ, Hu L, Qin YR, Liu HB, Zeng TT, Chen LL, Fu L, Deng W, Chen SP, Jia WH, Zhang CY, Xie D, Guan XY.  Characterization of a novel mechanism of genomic instability involving SEI1/SET/NM23H1 pathway in esophageal cancers.  Cancer Res. 2010Jul 15.70(14):5695-705.
      4. Huang PY, Zeng TT, Ban X, Li MQ, Zhang BZ, Zhu YH, Hua WF, Mai HQ, Zhang L, Guan XY*, Li Y*. Expression of EIF5A2 associates with poor survival of nasopharyngeal carcinoma patients treated with induction chemotherapy. BMC Cancer. 2016 Aug 22;16:669. doi: 10.1186/s12885-016-2714-2.
      5. Yang H, Li XD, Zhou Y, Ban X, Zeng TT, Li L, Zhang BZ, Yun J, Xie D, Guan XY, Li Y*. Stemness and chemotherapeutic drug resistance induced by EIF5A2 overexpression in esophageal squamous cell carcinoma. Oncotarget. 2015 Sep 22;6(28):26079-89.
      6. Li H, Zhang J, Chen SW, Liu LL, Li L, Gao F, Zhuang SM, Wang LP, Li Y*, Song M*. Cancer-associated fibroblasts provide a suitable microenvironment for tumor development and progression in oral tongue squamous cancer. J Transl Med. 2015 Jun 21;13(1):198.
      7. Song Y, Li J, Zhu Y, Dai Y, Zeng T, Liu L, Li J, Wang H, Qin Y, Zeng M, Guan XY*, Li Y*. MicroRNA-9 promotes tumor metastasis via repressing E-cadherin in esophageal squamous cell carcinoma. Oncotarget. 2014 Nov 30;5(22):11669-80.
      8. Huang PY, Zeng TT, Li MQ, Ban X, Zhu YH, Zhang BZ, Mai HQ, Zhang L, Guan XY*, Li Y*. Proteomic analysis of a nasopharyngeal carcinoma cell line and a nasopharyngeal epithelial cell line. Tumori. 2015 Nov 14;101(6):676-83. 
      9. Huang PY, Li Y, Luo DH, Hou X, Zeng TT, Li MQ, Mai HQ, Zhang L. Expression of Aurora-B and FOXM1 predict poor survival in patients with nasopharyngeal carcinoma. StrahlentherOnkol. 2015 Aug;191(8):649-55.  (SCI 2.898)
      10. Li Y*, Zhu CL, Nie CJ, Li JC, Zeng TT, Zhou J, Chen J, Chen K, Fu L, Liu H, Qin Y, Guan XY*.  Investigation of Tumor Suppressing Function of CACNA2D3 in Esophageal Squamous Cell Carcinoma. PLoS One. 2013;8(4):e60027. 
      11. Huang PY, Li Y, Mai HQ, Luo RZ, Cai YC, Zhang L. Expression of ERCC1 predicts clinical outcome in locoregionally advanced nasopharyngeal carcinoma treated with cisplatin-based induction chemotherapy.OralOncol. 2012 Oct;48(10):964-8. (SCI 3.607) (Co-first)
      12. Li Y*, Guan XY*. EIF5A2 promotes tumor metastasis and angiogenesis.  ScienceProceedings  2014;1:e381.
      13. Li Y, Shao JY, Liu RY, Zhou L, Chai LP, Li HL, Han HY, Huang BJ, Zeng MS, Zhu XF, Liu Q, Fu LW, Huang W. Evaluation of long-term toxicity of Ad/hIFN-, an Adenoviral vector encoding the human interferon-gamma gene, in nonhuman primates. Hum Gene Ther. 2008 Aug;19(8):827-39.
      14. Chen K, Li Y*, Dai Y, Li J, Qin Y, Zhu Y, Zeng T, Ban X, Fu L, Guan XY*. Characterization of Tumor Suppressive Function of cornulin in Esophageal Squamous Cell Carcinoma. PLoS One. 2013 Jul 24;8(7):e68838. doi: 10.1371/journal.pone.0068838. 
      15. Xue G, Liu RY, Li Y, Cheng Y, Liang ZH, Wu JX, Zeng MS, Tian FZ, Huang W. Dendritic cells modified with 6Ckine/IFNgamma fusion gene induce specific cytotoxic T lymphocytes in vitro. Cancer ImmunolImmunother. 2007 Nov;56(11):1831-43. (Co-first author)

    联系方式:liyan@sysucc.org.cn or liy6@mail.sysu.edu.cn

     
      更新时间:2017.3.1
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