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  • 李焱

    职称:
    职务:博士,副研究员, 硕士生导师
    专长:从事肿瘤的发病机制和防治研究
        李焱,博士,副研究员, 硕士生导师( 肿瘤学和分子医学专业), 中山大学肿瘤防治中心, 华南肿瘤学国家重点实验室工作,从事肿瘤的发病机制和防治研究。
        主持多项基金包括:国家自然科学基金(81172338和30700820),广东省教育厅科技创新项目,中山大学优秀青年教师重点培育计划,广东省卫生厅基金等。并参与多项科研项目如973、863和国家科技重大专项等研究。作为参与者获得了高等学校自然科学奖一等奖(No.2010-030),广东省科学技术奖一等奖(A03-0-1-01),中华医学科技奖三等奖,中国高校科技进步二等奖(教育部)。是World Journal of Gastroenterology的编委会成员和Plos One, Chinese Journal of Cancer, Journal of Cell Science & Molecular Biology杂志的审稿人。

        李焱,博士,副研究员, 硕士生导师( 肿瘤学和分子医学专业), 中山大学肿瘤防治中心, 华南肿瘤学国家重点实验室工作,从事肿瘤的发病机制和防治研究。主持多项基金包括:国家自然科学基金(81472255,81172338和30700820),广东省教育厅科技创新项目,广东省自然基金,中山大学优秀青年教师重点培育计划,广东省卫生厅基金等。并参与多项科研项目如973、863和国家科技重大专项等研究。作为参与者获得了高等学校自然科学奖一等奖(No.2010-030),广东省科学技术奖一等奖(A03-0-1-01),中华医学科技奖三等奖,中国高校科技进步二等奖(教育部)。是World Journal of Gastroenterology和The New American Journal of Gastroenterology & Hepatology的编委会成员和Plos One, Chinese Journal of Cancer, Journal of Cell Science & Molecular Biology, World Journal of Surgical Oncology, Bioscience Reports, International Journal of Experimental Pathology杂志的审稿人。

    教育背景和留学经历:
      1996-2001 原中山医科大学,获博士学位
      2004-2005 Yale University Cancer Center, 博士后研究

    近年来发表文章目录:(*通讯作者)
      1. Song Y, Li J, Zhu Y, Dai Y, Zeng T, Liu L, Li J, Wang H, Qin Y, Zeng M, Guan XY*, Li Y*. MicroRNA-9 promotes tumor metastasis via repressing E-cadherin in esophageal squamous cell carcinoma. Oncotarget. 2014 Nov 30;5(22):11669-80.(SCI 6.627)(共同通讯作者)
      2. Li Y*, Fu L, Li JB, Qin Y, Zeng TT, Zhou J, Zeng ZL, Chen J, Cao TT, Ban X, Qian C, Cai Z, Xie D, Huang P, Guan XY*. Increased Expression of EIF5A2, via Hypoxia or Gene Amplification, Contributes to Metastasis and Angiogenesis of Esophageal Squamous Cell Carcinoma. Gastroenterology. 2014 Jun;146(7):1701-1713.(共同通讯作者)(SCI 13.926)
      3. Li Y*, Zhu CL, Nie CJ, Li JC, Zeng TT, Zhou J, Chen J, Chen K, Fu L, Liu H, Qin Y, Guan XY*.  Investigation of Tumor Suppressing Function of CACNA2D3 in Esophageal Squamous Cell Carcinoma. PLoS One. 2013;8(4):e60027. (SCI  3.73) (共同通讯作者)
      4. Chen K, Li Y*, Dai Y, Li J, Qin Y, Zhu Y, Zeng T, Ban X, Fu L, Guan XY*. Characterization of Tumor Suppressive Function of cornulin in Esophageal Squamous Cell Carcinoma. PLoS One. 2013 Jul 24;8(7):e68838. doi: 10.1371/journal.pone.0068838.   (共同通讯作者) (SCI 3.73)
      5. Huang PY, Li Y, Mai HQ, Luo RZ, Cai YC, Zhang L. Expression of ERCC1 predicts clinical outcome in locoregionally advanced nasopharyngeal carcinoma treated with cisplatin-based induction chemotherapy.Oral Oncol. 2012 Oct;48(10):964-8. (SCI 2.695) (Co-first)
      6. Li Y, Chen L, Nie CJ, Zeng TT, Liu H, Mao X, Qin Y, Zhu YH, Fu L, Guan XY. Downregulation of RBMS3 is associated with poor prognosis in esophageal squamous cell carcinoma. Cancer Res. 2011; 71(19):6106-15. (SCI 8.65 )
      7. Li Y, Nie CJ, Hu L, Qin YR, Liu HB, Zeng TT, Chen LL, Fu L, Deng W, Chen SP, Jia WH, Zhang CY, Xie D, Guan XY.  Characterization of a novel mechanism of genomic instability involving SEI1/SET/NM23H1 pathway in esophageal cancers.  Cancer Res.  2010.70(14):5695-705. (SCI 8.65 )
      8. Li Y, Shao JY, Liu RY, Zhou L, Chai LP, Li HL, Han HY, Huang BJ, Zeng MS, Zhu XF, Liu Q, Fu LW, Huang W. Evaluation of long-term toxicity of Ad/hIFN-, an Adenoviral vector encoding the human interferon-gamma gene, in nonhuman primates. Hum Gene Ther. 2008 Aug;19(8):827-39. (SCI 4.019)
      9. Dai Y, Liu L, Zeng T, Zhu YH, Li J, Chen L, Li Y, Yuan YF, Ma S, Guan XY. Characterization of the oncogenic function of centromere protein F in hepatocellular carcinoma. Biochem Biophys Res Commun. 2013 Jun 17. doi:pii: S0006-291X(13)00995-9. 10.1016/j.bbrc.2013.06.021. (SCI 2.406)
      10. Li J, Li X, Li Y, Yang H, Wang L, Qin Y, Liu H, Fu L, Guan XY. Cell-specific detection of miR-375 downregulation for predicting the prognosis of esophageal squamous cell carcinoma by miRNA in situ hybridization. PLoS One. 2013;8(1):e53582. (SCI 3.73)
      11. Chen L, Li Y, Lin CH, Chan TH, Chow RK, Song Y, Liu M, Yuan YF, Fu L, Kong KL, Qi L, Li Y, Zhang N, Tong AH, Kwong DL, Man K, Lo CM, Lok S, Tenen DG, Guan XY. Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma. Nat Med. 2013 Feb;19(2):209-16. (SCI 22.864)
      12. Chen L, Yuan YF, Li Y, Chan TH, Zheng BJ, Huang J, Guan XY.  Clinical significance of CHD1L in hepatocellular carcinoma and therapeutic potentials of virus-mediated CHD1L depletion. Gut. 2011 Apr;60(4):534-43. (SCI 10.732)
      13. Wang J, Chen L, Li Y, Guan XY. Overexpression of cathepsin z contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma. PLoS One. 2011;6(9):e24967 Epub 2011 Sep 22 (SCI 3.73)
      14. Li J, Yang H, Chen L, Li Y, Zhu Y, Dai Y, Chen K, Ai J, Zeng T, Mao X, Liu L, Li X, Guan XY.  Establishment and characterization of human non-small cell lung cancer cell lines. Mol Med Report. 2012 Jan;5(1):114-7. doi: 10.3892/mmr.2011.613. Epub 2011 Oct 3. (SCI 1.17)
      15. Zhu YH, Fu L, Chen L, Qin YR, Liu H, Xie F, Zeng T, Dong SS, Li J, Li Y, Dai Y, Xie D, Guan XY. Downregulation of the Novel Tumor Suppressor DIRAS1 Predicts Poor Prognosis in Esophageal Squamous Cell Carcinoma. Cancer Res. 2013 Apr 1;73(7):2298-309. (SCI 8.65)
      16. Huang Y, Li LZ, Zhang CZ, Yi C, Liu LL, Zhou X, Xie GB, Cai MY, Li Y, Yun JP. Decreased expression of zinc-alpha2-glycoprotein in hepatocellular carcinoma associates with poor prognosis. J Transl Med. 2012 May 24;10:106. doi: 10.1186/1479-5876-10-106. (SCI 3.459)
      17. Chen J, Kwong DL, Zhu CL, Chen LL, Dong SS, Zhang LY, Tian J, Qi CB, Cao TT, Wong AM, Kong KL, Li Y, Liu M, Fu L, Guan XY. RBMS3 at 3p24 Inhibits Nasopharyngeal Carcinoma Development via Inhibiting Cell Proliferation, Angiogenesis, and Inducing Apoptosis. PLoS One. 2012;7(9):e44636. Epub 2012 Sep5  (SCI 3.73)
      18. Liu M, Chen LL, Chan TH, Wang J, Li Y, Li Y, Zeng TT, Yuan YF, Guan XY. Serum and glucocorticoid kinase 3 at 8q13.1 promotes cell proliferation and survival in hepatocellular carcinoma. Hepatology. 2012 Jun;55(6):1754-65. (SCI 12.003)
      19. Fu L, Zhang C, Zhang LY, Dong SS, Lu LH, Chen J, Dai Y, Li Y, Kong KL, Kwong DL, Guan XY. Wnt2 secreted by tumour fibroblasts promotes tumour progression in oesophageal cancer by activation of the Wnt/β-catenin signalling pathway. Gut. 2011 Dec;60(12):1635-43. Epub 2011 Jun 14. (SCI 10.732)
      20. Xie F, Liu H, Zhu YH, Qin YR, Dai Y, Zeng T, Chen L, Nie C, Tang H, Li Y, Fu L, Guan XY. Overexpression of GPR39 contributes to malignant development of human esophageal squamous cell carcinoma. BMC Cancer. 2011 Feb 25;11:86. (SCI 3.333)
      21. Qin YR, Tang H, Xie F, Liu H, Zhu Y, Ai J, Chen L, Li Y, Kwong DL, Fu L, Guan XY. Characterization of tumor-suppressive function of SOX6 in human esophageal squamous cell carcinoma.Clin Cancer Res. 2011 Jan 1;17(1):46-55. Epub 2010 Nov 17. (SCI 7.837)
      22. Kong KL, Kwong DL, Fu L, Chan TH, Chen L, Liu H, Li Y, Zhu YH, Bi J, Qin YR, Law SY, Guan XY. Characterization of a candidate tumor suppressor gene uroplakin 1A in esophageal squamous cell carcinoma. Cancer Res. 2010 Nov 1;70(21):8832-41. Epub 2010 Oct 26. (SCI 8.65 )
      23. Wen J, Zheng B, Hu Y, Zhang X, Yang H, Li Y, Zhang CY, Luo KJ, Zang X, Li YF, Guan XY, Fu JH. Comparative proteomic analysis of the esophageal squamous carcinoma cell line EC109 and its multi-drug resistant subline EC109/CDDP.  Int J Oncol. 2010 Jan;36(1):265-74. (SCI 2.657)
      24. Chen L, Chan TH, Yuan YF, Hu L, Huang J, Ma S, Wang J, Dong SS, Tang KH, Xie D, Li Y, Guan XY. CHD1L promotes hepatocellular carcinoma progression and metastasis in mice and is associated with these processes in human patients. J Clin Invest. 2010 Apr 1;120(4):1178-91. doi: 10.1172/JCI40665. Epub 2010 Mar 24. (SCI 12.812)
      25. Fu L, Dong SS, Xie YW, Tai LS, Chen L, Kong KL, Man K, Xie D, Li Y, Cheng Y, Tao Q, Guan XY.  Down-regulation of tyrosine aminotransferase at a frequently deleted region 16q22 contributes to the pathogenesis of hepatocellular carcinoma. Hepatology. 2010 May;51(5):1624-34. (SCI  12.003)
      26. Zhang C, Fu L, Fu J, Hu L, Yang H, Rong TH, Li Y, Liu H, Fu SB, Zeng YX, Guan XY. Fibroblast growth factor receptor 2-positive fibroblasts provide a suitable micro -environment for tumor development and progression in esophageal carcinoma. Clin Cancer Res. 2009 Jun 15; 15(12):4017-27.  (SCI 7.837)
      27. Tang DJ, Dong SS, Ma NF, Xie D, Chen L, Fu L, Lau SH, Li Y, Li Y, Guan XY. Overexpression of EIF5A2 enhances cell motility and promotes tumor metastasis in hepatocellular carcinoma. Hepatology. 2009; Apr;51(4):1255-63 (SCI  12.003)
      28. Qin YR, Fu L, Sham PC, Kwong DL, Zhu CL, Chu KK, Li Y, Guan XY. Single-nucleotide polymorphism-mass array reveals commonly deleted regions at 3p22 and 3p14.2 associate with poor clinical outcome in esophageal squamous cell carcinoma. Int J Cancer. 2008 Aug 15;123(4):826-30. (SCI 6.198)

    联系方式:liyan@sysucc.org.cn or liy6@mail.sysu.edu.cn

                 更新时间:2015.6.23

    
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