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  • 曾木圣

    职务:中心副主任、副院长
    职称:博士、研究员、博士生导师、华南肿瘤学国家重点实验室肿瘤病毒与生物标记研究室PI
    专长:恶性肿瘤发病机制、早期诊断和预后研究
    姓名:曾木圣
    职称: 博士、研究员、博士生导师、华南肿瘤学国家重点实验室肿瘤病毒与生物标记研究室PI
    职务: 中心副主任、副院长
    专长: 恶性肿瘤发病机制、早期诊断和预后研究

      2003年回国后被中山大学肿瘤防治中心聘为副研究员,组建肿瘤病毒学和肿瘤分子标志研究组;2006年聘为研究员,博士生导师,同年入选“教育部新世纪优秀人才计划”; 2010年入选广东省“千百十人才国家级培养对象”,并获2010年“国家杰出青年科学基金”项目资助;2016年入选广东省高层次人才特殊支持计划“杰出人才”(南粤百杰)。现任中山大学肿瘤防治中心副主任、副院长,中国抗癌协会理事,广东省抗癌协会第四届理事会常务理事、秘书长,中国抗癌协会肿瘤标志专业委员会副主任委员,中国抗癌协会肿瘤微环境专业委员会副主任委员。当选2022年Gordon Research Conference国际鼻咽癌会议主席,曾任国际EB病毒及相关疾病协会理事,兼任Cancer communications,Scientific Data等杂志编委。长期致力于病毒与肿瘤的基础研究,发表高水平收录论文70余篇。2018年以第一完成人的项目“EB病毒相关鼻咽癌病因、发病机制及其分子标志”获得广东省自然科学奖一等奖。

    学科:1) 肿瘤学 2)生物化学与分子生物学 3)医学微生物学
    专业特长:恶性肿瘤发病机制、早期诊断和预后研究
    研究方向:
      1. 肿瘤病毒感染、致癌机制与免疫调控
      2. 肿瘤疫苗
      3. 分子影像及靶向治疗

    联系电话:020-87343191;(Fax):020-87342021, Email: zengmsh@sysucc.org.cn
    通讯地址:广州市东风东路651号 中山大学肿瘤防治中心实验研究部 邮编 510060

    教育经历
      1988年毕业于江西医学院抚州分院(现南昌大学抚州医学院) 
      1994年毕业于中山大学(原中山医科大学),获肿瘤学硕士学位
      1998年毕业于中山大学(原中山医科大学),获微生物学博士学位

    留学经历
      1999-2000年美国田纳西州立大学生物系(Tennessee State University)博士后,从事维甲酸在细胞发育及分化中作用的研究
      2000-2003年美国波士顿塔夫茨大学—新英格兰医学中心(Tufts University-New England Medical Center)肿瘤生物学实验室从事HPV致癌机制研究
    姓名:曾木圣
    职称: 博士、研究员、博士生导师、华南肿瘤学国家重点实验室肿瘤病毒与生物标记研究室PI
    职务: 中心副主任、副院长
    专长: 恶性肿瘤发病机制、早期诊断和预后研究

      2003年回国后被中山大学肿瘤防治中心聘为副研究员,组建肿瘤病毒学和肿瘤分子标志研究组;2006年聘为研究员,博士生导师,同年入选“教育部新世纪优秀人才计划”; 2010年入选广东省“千百十人才国家级培养对象”,并获2010年“国家杰出青年科学基金”项目资助;2016年入选广东省高层次人才特殊支持计划“杰出人才”(南粤百杰)。现任中山大学肿瘤防治中心副主任、副院长,中国抗癌协会理事,广东省抗癌协会第四届理事会常务理事、秘书长,中国抗癌协会肿瘤标志专业委员会副主任委员,中国抗癌协会肿瘤微环境专业委员会副主任委员。当选2022年Gordon Research Conference国际鼻咽癌会议主席,曾任国际EB病毒及相关疾病协会理事,兼任Cancer communications,Scientific Data等杂志编委。长期致力于病毒与肿瘤的基础研究,发表高水平收录论文70余篇。2018年以第一完成人的项目“EB病毒相关鼻咽癌病因、发病机制及其分子标志”获得广东省自然科学奖一等奖。

    学科:1) 肿瘤学 2)生物化学与分子生物学 3)医学微生物学
    专业特长:恶性肿瘤发病机制、早期诊断和预后研究
    研究方向:
      1. 肿瘤病毒感染、致癌机制与免疫调控
      2. 肿瘤疫苗
      3. 分子影像及靶向治疗

    联系电话:020-87343191;(Fax):020-87342021, Email: zengmsh@sysucc.org.cn
    通讯地址:广州市东风东路651号 中山大学肿瘤防治中心实验研究部 邮编 510060

    教育经历
      1988年毕业于江西医学院抚州分院(现南昌大学抚州医学院) 
      1994年毕业于中山大学(原中山医科大学),获肿瘤学硕士学位
      1998年毕业于中山大学(原中山医科大学),获微生物学博士学位

    留学经历
      1999-2000年美国田纳西州立大学生物系(Tennessee State University)博士后,从事维甲酸在细胞发育及分化中作用的研究
      2000-2003年美国波士顿塔夫茨大学—新英格兰医学中心(Tufts University-New England Medical Center)肿瘤生物学实验室从事HPV致癌机制研究

    科研成就
      回国后组建肿瘤病毒学和肿瘤分子标志研究组,首次完成鼻咽癌相关EBV全序列分析,发现鼻咽癌相关的EBV序列特征【J Virol 2005,入选第一届中国百篇最具影响优秀国际学术论文(科技部直属中国科学技术信息研究所评选)】,证实高发区NPC相关EBV亚型的假设;揭示吸烟可以通过激活EBV参与鼻咽癌发病的新机制。发现EBV-LMP2A通过诱导上皮间质转化和肿瘤启动细胞群体参与鼻咽癌发生发展的新机制;发现EBV可以诱导原癌基因Bmi-1的表达,阐明Bmi-1在鼻咽上皮细胞早期转化和鼻咽癌侵袭和转移中的作用,揭示PTEN/PI3K/Akt/Snail通路介导Bmi-1诱导上皮间质转化和肿瘤转移的新机制。建立首个单一原癌基因诱导的鼻咽上皮细胞永生化模型和EBV高效感染上皮细胞的体外模型,鉴定出EBV感染上皮细胞的关键受体或共受体(NRP1、MHC-IIA、EphA2等),系统阐明EBV进入鼻咽上皮细胞的机制,近期联合上海药物研究所余学奎课题组报道了高分辨率EBV病毒衣壳全原子结构模型,为鼻咽癌预防和干预研究提供了新思路。揭示了食管鳞状上皮细胞癌的癌前病变的基因组特征及其与肿瘤的演化发展关系,发现新融合基因RARS-MAD1L1及其在鼻咽癌和头颈肿瘤中作用与机制。至2020年止,作为主持人牵头国家重点研发计划1项、主持国家自然科学基金重点项目和国际合作重大项目共4项、“863”课题及“973”课题各1项等。发表高水平收录论文70余篇,包括国际上重要专业性杂志Nature Microbiol, Cell Res, Cancer Cell, J Clin Invest, Nature Commun, PNAS, J Natl Cancer Inst, PLoS Pathog, EMBO Mol Med, EMBO Rep, Cancer Res, Clin Cancer Resh, Ann Oncol, Mol Cancer, J Virol, J Biol Chem等。

    主持的主要科研项目
    1.国家自然科学基金重点项目,81830090,鼻咽癌中YTHDF1复合体降解病毒m6A修饰RNA调控EBV感染状态及肿瘤进展,2019-2023 
    2.国家重点研发计划项目负责人“基于基因组不稳定性的新型蛋白质机器在肿瘤发生发展中的作用、机制及干预”,2017-2022 
    3.国家重点研发计划子课题参与人“疱疹病毒感染与致病过程中蛋白质机器的功能机制”2016-2021 
    4.国家自然科学基金国际(地区)合作与交流项目,81520108022,EB病毒进入鼻咽上皮细胞受体鉴定及感染机制,2016-2020 
    5.国家自然科学基金重大研究计划,91440106,RNA结合蛋白RBM24调控miR-25-3p及lncRNA MALAT1抑制鼻咽癌的机制,2015-2017
    6.国家自然科学基金重点项目,81230045,融合基因AARS-MADx诱导基因组不稳定性及参与鼻咽癌发生的机制,2013-2017 
    7.“973”课题:“致瘤病毒感染和致癌机制”,2011-2017 
    8.国家自然科学基金杰出青年基金,81025014,头颈肿瘤,2011-2014 
    9.国家自然科学基金重点项目,30630068,鼻咽癌早期诊断的基础研究,2007-2010 
    10.“863”计划课题(2007AA02Z477)鼻咽癌早期诊断新方法研究,2007-2010 

    代表性研究成果
    1.Zhang A; Xing J; Xia T; Zhang H; Fang M; Li S; Du Y; Li X C; Zhang Z*; Zeng M S*, EphA2 phosphorylates NLRP3 and inhibits inflammasomes in airway epithelial cells. EMBO Rep, 2020, 21(7):e49666.
    2.Li S B; Liu Y Y; Yuan L; Ji M F; Zhang A; Li H Y; Tang L Q; Fang S G; Zhang H; Xing S; Li M Z; Zhong Q; Lin S J; Liu W L; Huang P; Zeng Y X; Zheng Y M; Ling Z Q*; Sui J H*; Zeng M S*, Autocrine INSL5 promotes tumor progression and glycolysis via activation of STAT5 signaling. EMBO Mol Med, 2020,:e12050.
    3.Li Z; Zhang X; Dong L; Pang J; Xu M; Zhong Q; Zeng M S*; Yu X*, CryoEM structure of the tegumented capsid of Epstein-Barr virus. Cell Res, 2020,.
    4.Zhang X; Zhao B; Ding M; Song S; Kang Y; Yu Y; Xu M; Xiang T; Gao L; Feng Q; Zhao Q; Zeng M S*; Krummenacher C*; Zeng Y X*, A novel vaccine candidate based on chimeric virus-like particle displaying multiple conserved epitope peptides induced neutralizing antibodies against EBV infection. Theranostics, 2020, 10(13):5704-5718.
    5.Xue R; Chen L; Zhang C; Fujita M; Li R; Yan S M; Ong C K; Liao X; Gao Q; Sasagawa S; Li Y; Wang J; Guo H; Huang Q T; Zhong Q; Tan J; Qi L; Gong W; Hong Z; Li M; Zhao J; Peng T; Lu Y; Lim K; Boot A; Ono A; Chayama K; Zhang Z; Rozen S G; Teh B T; Wang X W; Nakagawa H*; Zeng M S*; Bai F*; Zhang N*, Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic  Cholangiocarcinoma Reveals Distinct Molecular Subtypes. Cancer Cell, 2019, 35(6):932-947.e8.
    6.Wu Y; Liu S X; Wang F; Zeng M S*, Room Temperature Detection of Plasma Epstein-Barr Virus DNA with CRISPR-Cas13. Clin Chem, 2019, 65(4):591-592.
    7.Wang C; Jiang S; Ke L; Zhang L; Li D; Liang J; Narita Y; Hou I; Chen C H; Wang L; Zhong Q; Ling Y; Lv X; Xiang Y; Guo X; Teng M; Tsao S W; Gewurz B E; Zeng M S*; Zhao B*, Genome-wide CRISPR-based gene knockout screens reveal cellular factors and pathways essential for nasopharyngeal carcinoma. J Biol Chem, 2019, 294(25):9734-9745.
    8.Feng G K; Ye J C; Zhang W G; Mei Y; Zhou C; Xiao Y T; Li X L; Fan W*; Wang F*; Zeng M S*, Integrin α6 targeted positron emission tomography imaging of hepatocellular carcinoma in mouse models. J Control Release, 2019, 310:11-21.
    9.Zhang H; Li Y; Wang H B; Zhang A; Chen M L; Fang Z X; Dong X D; Li S B; Du Y; Xiong D; He J Y; Li M Z; Liu Y M; Zhou A J; Zhong Q; Zeng Y X; Kieff E; Zhang Z; Gewurz B E; Zhao B*; Zeng M S*, Ephrin receptor A2 is an epithelial cell receptor for Epstein-Barr virus entry. Nat Microbiol, 2018, 3(2):1-8.
    10.Zhong Q; Liu Z H; Lin Z R; Hu Z D; Yuan L; Liu Y M; Zhou A J; Xu L H; Hu L J; Wang Z F; Guan X Y; Hao J J; Lui V; Guo L; Mai H Q; Chen M Y; Han F; Xia Y F; Grandis J R; Zhang X*; Zeng M S*, The RARS-MAD1L1 Fusion Gene Induces Cancer Stem Cell-like Properties and Therapeutic Resistance in Nasopharyngeal Carcinoma. Clin Cancer Res, 2018, 24(3):659-673.
    11.Wang Q; Li S B; Zhao Y Y; Dai D N; Du H; Lin Y Z; Ye J C; Zhao J; Xiao W; Mei Y; Xiao Y T; Liu S C; Li Y; Xia Y F; Song E W; Tang G H; Zhang W G; Li Z J; Zheng X B; Cao D H; Li M Z; Zhong Q; Chen Z P; Qian C N; Fan W; Feng G K; Zeng M S*, Identification of a sodium pump Na(+)/K(+) ATPase α1-targeted peptide for PET imaging of breast cancer. J Control Release, 2018, 281:178-188.
    12.Chen X X; Zhong Q; Liu Y; Yan S M; Chen Z H; Jin S Z; Xia T L; Li R Y; Zhou A J; Su Z; Huang Y H; Huang Q T; Huang L Y; Zhang X; Zhao Y N; Yun J P; Wu Q L; Lin D X; Bai F*; Zeng M S*, Genomic comparison of esophageal squamous cell carcinoma and its precursor lesions by multi-region whole-exome sequencing. Nat Commun, 2017, 8(1):524.
    13.Xing J; Zhang A; Zhang H; Wang J; Li X C*; Zeng M S*; Zhang Z*, TRIM29 promotes DNA virus infections by inhibiting innate immune response. Nat Commun, 2017, 8(1):945.
    14.Tang L Q; Li C F; Li J; Chen W H; Chen Q Y; Yuan L X; Lai X P; He Y; Xu Y X; Hu D P; Wen S H; Peng Y T; Zhang L; Guo S S; Liu L T; Guo L; Wu Y S; Luo D H; Huang P Y; Mo H Y; Xiang Y Q; Sun R; Chen M Y; Hua Y J; Lv X; Wang L; Zhao C; Cao K J; Qian C N; Guo X; Zeng Y X*; Mai H Q*; Zeng M S*, Establishment and Validation of Prognostic Nomograms for Endemic Nasopharyngeal Carcinoma. J Natl Cancer Inst, 2016, 108(1).
    15.Hua W F; Zhong Q; Xia T L; Chen Q; Zhang M Y; Zhou A J; Tu Z W; Qu C; Li M Z; Xia Y F; Wang H Y; Xie D; Claret F X; Song E W; Zeng M S*, RBM24 suppresses cancer progression by upregulating miR-25 to target MALAT1 in nasopharyngeal carcinoma. Cell Death Dis, 2016, 7(9):e2352.
    16.Wang H B; Zhang H; Zhang J P; Li Y; Zhao B; Feng G K; Du Y; Xiong D; Zhong Q; Liu W L; Du H; Li M Z; Huang W L; Tsao S W; Hutt-Fletcher L; Zeng Y X; Kieff E; Zeng M S*, Neuropilin 1 is an entry factor that promotes EBV infection of nasopharyngeal  epithelial cells. Nat Commun, 2015, 6:6240.
    17.Ni C; Chen Y; Zeng M(co-first author); Pei R; Du Y; Tang L; Wang M; Hu Y; Zhu H; He M; Wei X; Wang S; Ning X; Wang M; Wang J; Ma L; Chen X; Sun Q; Tang H; Wang Y; Wang X*, In-cell infection: a novel pathway for Epstein-Barr virus infection mediated by cell-in-cell structures. Cell Res, 2015, 25(7):785-800.
    18.Xiong D; Du Y; Wang H B; Zhao B; Zhang H; Li Y; Hu L J; Cao J Y; Zhong Q; Liu W L; Li M Z; Zhu X F; Tsao S W; Hutt-Fletcher L M; Song E; Zeng Y X; Kieff E*; Zeng M S*, Nonmuscle myosin heavy chain IIA mediates Epstein-Barr virus infection of nasopharyngeal epithelial cells. Proc Natl Acad Sci U S A, 2015, 112(35):11036-41.
    19.Feng G K; Liu R B; Zhang M Q; Ye X X; Zhong Q; Xia Y F; Li M Z; Wang J; Song E W; Zhang X*; Wu Z Z*; Zeng M S*, SPECT and near-infrared fluorescence imaging of breast cancer with a  neuropilin-1-targeting peptide. J Control Release, 2014, 192:236-42.
    20.Yuan L; Liu Z H; Lin Z R; Xu L H; Zhong Q*; Zeng M S*, Recurrent FGFR3-TACC3 fusion gene in nasopharyngeal carcinoma. Cancer Biol Ther, 2014, 15(12):1613-21.
    21.Zhang J P; Zhang H; Wang H B; Li Y X; Liu G H; Xing S; Li M Z; Zeng M S*, Down-regulation of Sp1 suppresses cell proliferation, clonogenicity and the expressions of stem cell markers in nasopharyngeal carcinoma. J Transl Med, 2014, 12:222.
    22.Tang L Q; Chen Q Y; Fan W; Liu H; Zhang L; Guo L; Luo D H; Huang P Y; Zhang X; Lin X P; Mo Y X; Liu L Z; Mo H Y; Li J; Zou R H; Cao Y; Xiang Y Q; Qiu F; Sun R; Chen M Y; Hua Y J; Lv X; Wang L; Zhao C; Guo X; Cao K J; Qian C N; Zeng M S*; Mai H Q*, Prospective study of tailoring whole-body dual-modality [18F]fluorodeoxyglucose  positron emission tomography/computed tomography with plasma Epstein-Barr virus DNA for detecting distant metastasis in endemic nasopharyngeal carcinoma at initial  staging. J Clin Oncol, 2013, 31(23):2861-9.
    23.Wang H B; Liu G H; Zhang H; Xing S; Hu L J; Zhao W F; Xie B; Li M Z; Zeng B H; Li Y; Zeng M S*, Sp1 and c-Myc regulate transcription of BMI1 in nasopharyngeal carcinoma. FEBS J, 2013, 280(12):2929-44.
    24.Zou Q F; Du JK; Zhang H; Wang H B; Hu Z D; Chen S P; Du Y; Li M Z; Xie D; Zou J; Sun H D; Pu J X*; Zeng M S*, Anti-tumour activity of longikaurin A (LK-A), a novel natural diterpenoid, in nasopharyngeal carcinoma. J Transl Med, 2013, 11:200.
    25.Xu F H; Xiong D; Xu Y F; Cao S M; Xue W Q; Qin H D; Liu W S; Cao J Y; Zhang Y; Feng Q S; Chen L Z; Li M Z; Liu Z W; Liu Q; Hong M H; Shugart Y Y; Zeng Y X; Zeng M S*; Jia W H*, An epidemiological and molecular study of the relationship between smoking, risk of nasopharyngeal carcinoma, and Epstein-Barr virus activation. J Natl Cancer Inst, 2012, 104(18):1396-410.
    26.Guo B H; Feng Y; Zhang R; Xu L H; Li M Z; Kung H F; Song L B; Zeng M S*, Bmi-1 promotes invasion and metastasis, and its elevated expression is correlated with an advanced stage of breast cancer. Mol Cancer, 2011, 10(1):10.
    27.Guo B H; Zhang X; Zhang H Z; Lin H L; Feng Y; Shao J Y; Huang W L; Kung H F; Zeng M S*, Low expression of Mel-18 predicts poor prognosis in patients with breast cancer. Ann Oncol, 2010, 21(12):2361-2369.
    28.Kong Q L; Hu L J; Cao J Y; Huang Y J; Xu L H; Liang Y; Xiong D; Guan S; Guo B H; Mai H Q; Chen Q Y; Zhang X; Li M Z; Shao J Y; Qian C N; Xia Y F; Song L B; Zeng Y X; Zeng M S*, Epstein-Barr virus-encoded LMP2A induces an epithelial-mesenchymal transition and increases the number of side population stem-like cancer cells in nasopharyngeal carcinoma. PLoS Pathog, 2010, 6(6):e1000940.
    29.Cao J Y; Liu L; Chen S P; Zhang X; Mi Y J; Liu Z G; Li M Z; Zhang H; Qian C N; Shao J Y; Fu L W; Xia Y F*; Zeng M S*, Prognostic significance and therapeutic implications of centromere protein F expression in human nasopharyngeal carcinoma. Mol Cancer, 2010, 9:237.
    30.Song L B; Li J; Liao W T; Feng Y; Yu C P; Hu L J; Kong Q L; Xu L H; Zhang X; Liu W L; Li M Z; Zhang L; Kang T B; Fu L W; Huang W L; Xia Y F; Tsao S W; Li M; Band V; Band H; Shi Q H*; Zeng Y X*; Zeng M S*, The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces  epithelial-mesenchymal transition in human nasopharyngeal epithelial cells. J Clin Invest, 2009, 119(12):3626-36.
    31.Liao W T; Song L B; Zhang H Z; Zhang X; Zhang L; Liu W L; Feng Y; Guo B H; Mai H Q; Cao S M; Li M Z; Qin H D; Zeng Y X; Zeng M S*, Centromere protein H is a novel prognostic marker for nasopharyngeal carcinoma progression and overall patient survival. Clin Cancer Res, 2007, 13(2 Pt 1):508-14.
    32.Song L B; Zeng M S*; Liao W T; Zhang L; Mo H Y; Liu W L; Shao J Y; Wu Q L; Li M Z; Xia Y F; Fu L W; Huang W L; Dimri G P; Band V; Zeng Y X, Bmi-1 is a novel molecular marker of nasopharyngeal carcinoma progression and immortalizes primary human nasopharyngeal epithelial cells. Cancer Res, 2006, 66(12):6225-32.
    33.Jiang R C; Qin H D; Zeng M S(co-first author); Huang W; Feng B J; Zhang F; Chen H K; Jia W H; Chen L Z; Feng Q S; Zhang R H; Yu X J; Zheng M Z; Zeng Y X*, A functional variant in the transcriptional regulatory region of gene LOC344967 cosegregates with disease phenotype in familial nasopharyngeal carcinoma. Cancer Res, 2006, 66(2):693-700.
    34.Zeng M; Zhang Y; Bhat I; Wazer D E; Band H; Band V*, The human kallikrein 10 promoter contains a functional retinoid response element. Biol Chem, 2006, 387(6):741-7.
    35.Zeng M S; Li D J; Liu Q L; Song L B; Li M Z; Zhang R H; Yu X J; Wang H M; Ernberg I; Zeng Y X*, Genomic sequence analysis of Epstein-Barr virus strain GD1 from a nasopharyngeal carcinoma patient. J Virol, 2005, 79(24):15323-30.
    36.Zeng M; Kumar A; Meng G; Gao Q; Dimri G; Wazer D; Band H; Band V*, Human papilloma virus 16 E6 oncoprotein inhibits retinoic X receptor-mediated transactivation by targeting human ADA3 coactivator. J Biol Chem, 2002, 277(47):45611-8.
    主要国际学术会议
    1.特邀会议报告:Title:The Key Cellular Factors in EBV Infection of Epithelial Cells, 2018 Nasopharyngeal Carcinoma Conference, Gordon Research Conference (GRC), Jun.24-Jun.29, 2018, HongKong, China
    2.大会秘书长:The 6th Guangzhou International Symposium on Oncology, Nov.30-Dec.2, 2017,  Guangzhou, China
    3.特邀会议报告:Title: Cellular Factors in Epstein-Barr Virus Infection of Nasopharyngeal Epithelial Cells, 17th International Symposium on EBV and associated diseases. August 8 to 12, 2016, Zurich, Switzerland
    4.特邀会议报告:Title, NPC, an Epithelial Cancer: Immortalization and Tumorigenesis. NPC Gordon Research Conference, June 26-July 1, 2016, Hong Kong, China
    5.大会秘书长:The 5th Guangzhou International Symposium on Oncology, Dec.1-3, 2016,  Guangzhou, China
    6.特邀会议报告:Title, NPC, The predictive /prognostic biomarker for nasopharyngeal carcinoma. Nasopharyngeal Carcinoma Symposium Biannual Meeting, Jun 3-6, 2015, Yogyakarta, Indonesia
    7.大会秘书长:The 4th Guangzhou International Symposium on Oncology, Nov.5-7, 2015,  Guangzhou, China
    8.特邀会议报告:Title:NRP1 interacts with gB and mediates EBV infection of nasopharyngeal epithelial cells. International Forum for hepesvirus, associated disease and antiviral development. Nov 15-16, 2014  Guangzhou,China
    9.特邀会议报告:Title:Epstein-Barr virus infection in nasopharyngeal carcinoma:Role in pathogenesis and therapeutic implications.Sino-German cancer,viruses and immune response symposium. May 13-14, 2014  Guangzhou,China
    10.受邀参加主题为“代谢异常与肿瘤”的第106期双清论坛  2014.1.7
    11.特邀报告:Nebraska大学特邀中美学术会议  2014.6.11
    12.特邀报告:中德学术研讨会  2014.5.12
    13.受邀参加主题为“上皮细胞可塑性与肿瘤发生发展”的第83期双清论坛  2012.10.31
    14.特邀报告:2012 international Congress on Oncogenic Herpesviruses and Associated Diseases  2012.8.1-8.4
    15.特邀报告:2012年全国肿瘤分子标志学术大会与国际肿瘤转化医学论坛暨第七届中国青年肿瘤专家论坛   2012.7.20-7.23
    16.主题发言:中美头颈肿瘤研讨会2012.1.6-1.7
    17.主题发言:中-法肿瘤学研讨会 2011.11.25-11.26
    18.主题发言: 17th International Charles Heidelberger Symposium on Cancer Research At The Fourth Military Medical University In Xi’an   2011.6.5-6.10
    19.分会报告: The Second Guangzhou International Symposium on Oncology 2011.5.18-5.20
    20.参会并大会发言:Title: Epstein-Barr Virus-Encoded LMP2A Induces EMT and Increases Side Population of Stem-like Cancer Cells in Nasopharyngeal Carcinoma. The 14th Biennial Conference of The International  Association for Research on Epstein-Barr Virus and Associated Diseases  Sept 5-72th ,2010, Birmingham,UK
    21.特邀会议报告:Title:Bmi-1, a polycomb group protein, plays an essential role in tumorigenesis and metastasis. 68th Annual Meeting of the Japanese Cancer Association, Oct 1-3, 2009. Yokohama
    22.特邀会议报告:Title:Bmi-1, a polycomb group protein, plays an essential role in tumorigenesis and metastasis. 2009年6月19日  国际癌症生物研讨会, 国立中山大学生物医学研究所, 高雄
    23.主办并大会报告:The 13th Biennial Conference of The International Association for Research on Epstein - Barr virus and Associated Diseases Nov. 7th— Nov.10th ,2008, 广州。参会代表300余人,包括国外及港台代表 220余人。
    24.特邀大会报告: Title:Cellular and Viral Oncogenes in NP Cell Transformation. AACR International Conference (Infection and Cancer: Biology, Therapeutics, and Prevention) Dec. 5th-7th, 2008. Hongkong
    25.特邀会议报告Title: The mechanism of EBV infection to nasopharyngeal epithelial cells.  The 7th Sino-Japan Joint Conference for Cancer Research December 7th~10th, 2008 Guangzhou, China
    26.参会并大会发言:Title: Bmi-1 is a Novel Molecular Marker of Nasopharyngeal Carcinoma Progression and Immortalizes Primary Human Nasopharyngeal Epithelial Cells.  The 12th Biennial Conference of The International Association for Research on Epstein-Barr Virus and Associated Diseases July 8-12th, 2006, Boston
    27.参会并大会发言:Title: Full-length sequencing and analysis of a EBV genome from a Cantonese NPC patient. East-West Symposium on NPC,2005,Toronto, Cannada

    学术兼职
    1.国际EB病毒及相关疾病协会理事会成员(2012-2014)
    2.中国抗癌协会理事
    3.中国抗癌协会肿瘤微环境专业委员会副主任委员(2019-)
    4.中国抗癌协会肿瘤标志专业委员会副主任委员 (2016-)
    5.中国抗癌协会肿瘤转移专业委员会常务委员 (2017-)
    6.广东省抗癌协会秘书长
    7.Scientific Data杂志编委(2014-)
    8.Cancer communication杂志编委


    更新日期:2020年8月4日
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