科研学者

邓蓉

职称：研究员，博士生导师

专长

肿瘤免疫逃逸及靶向治疗

邓蓉, 中山大学肿瘤防治中心研究员、博士生导师, 华南恶性肿瘤防治全国重点实验室学术秘书。现为中国老年保健协会肿瘤免疫治疗专业委员会副主任委员, 中国抗癌协会抗癌药物专业委员会常务委员, 中国药理学会肿瘤药理专业委员常务委员, 中国抗癌协会肿瘤精准治疗专委会常务委员。主要从事免疫原性死亡抵抗机制及其在肿瘤中应用的研究，相关论著入选ESI高被引论文。于2013年5月到2015年7月在美国MD Anderson Cancer Center从事博士后研究工作。已获主持包括国家自然科学基金 (5项) 、广东省自然科学基金在内的多项课题。申请专利九项，已获授权四项。

 

近5年代表性论著（*通讯作者，#第一作者）

  1. Hai-Liang Zhang#, Bing-Xin Hu#, Zhi-Peng Ye#, Zhi-Ling Li#, Shan Liu#, Wen-Qing Zhong, Tian Du, Dong Yang, Jia Mai, Li-Chao Li, Yu-Hong Chen, Xian-Ying Zhu, Xuan Li, Gong-Kan Feng, Xiao-Feng Zhu*, Rong Deng*. TRPML1 triggers ferroptosis defense and is a potential therapeutic target in AKT-hyperactivated cancer. Science Translational Medicine 2024,16(753): eadk0330.
  2. Hai-Liang Zhang, Bing-Xin Hu, Zhi-Ling Li, Tian Du, Jia-Lu Shan, Zhi-Peng Ye, Xiao-Dan Peng, Xuan Li, Yun Huang, Xian-Ying Zhu, Yu-Hong Chen, Gong-Kan Feng, Dajun Yang, Rong Deng*, Xiao-Feng Zhu*. PKCβII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis. Nature Cell Biology 2022, 24(1):88-98. 
  3. Jia-Lu Shan #, Kai-Ming Zhang #, Wen-Qing Zhong #, Xiao-Yu Yang #, Zhi-Ling Li, Yun Huang, Tian Du , Dong Yang , Jia-Hong Tang, Yu-Hong Chen , Hai-Liang Zhang , Xiao-Feng Zhu*, Rong Deng*. Reactivating cGAS-STING Signaling by Targeting SOS1 Enhances Antitumor Immunity in NRAS-Mutant Tumors. Cancer Research 2025, 85(16):3015-3031. 
  4. Yun Huang#, Wen-Qing Zhong#, Xiao-Yu Yang#, Jia-Lu Shan#, Ling Zhou, Zhi-Ling Li, Yi-Qing Guo, Kai-Ming Zhang, Tian Du, Hai-Liang Zhang, Bing-Xin Hu, Yu-Hong Chen, Dong Yang, Gong-Kan Feng, Jun Tang*, Xiao-Feng Zhu*, and Rong Deng*. Targeting site-specific N-glycosylated B7H3 induces potent antitumor immunity. Nature Communications. 2025, 16(1):3546.
  5. Kai-Ming Zhang#, De-Chang Zhao#, Ze-Yu Li#, Yan Wang#, Jian-Nan Liu, Tian Du, Ling Zhou, Yu-Hong Chen, Qi-Chao Yu, Qing-Shan Chen, Rui-Zhao Cai, Zi-Xuan Zhao, Jia-Lu Shan, Bing-Xin Hu, Hai-Liang Zhang, Gong-Kan Feng, Xiao-Feng Zhu, Jun Tang, Rong Deng*. Inactivated cGAS-STING Signaling Facilitates Endocrine Resistance by Forming a Positive Feedback Loop with AKT Kinase in ER+HER2- Breast Cancer. Advanced Science 2024,11(35): e2403592. 
  6. Jia Mai#, Xiao-Dan Peng#, Jun Tang#, Tian Du, Yu-Hong Chen, Zi-Feng Wang, Hai-Liang Zhang, Jun-Hao Huang, Zhuo-Yan Zhong, Dong Yang, Zhi-Ling Li, Yun Huang, Gong-Kan Feng, Xiao-Feng Zhu*, and Rong Deng*. AKT-Mediated Regulation of Chromatin ubiquitination and Tumorigenesis through Mel-18 Phosphorylation. Oncogene 2021,40: 2422-2436.
  7. Rong Deng#, Hai-Liang Zhang# , Jun-Hao Huang#, Rui-Zhao Cai#, Yan Wang ,Yu-Hong Chen, Bing-Xin Hu , Zhi-Peng Ye, Zhi-Ling Li, Jia Mai , Yun Huang, Xuan Li , Xiao-Dan Peng , Gong-Kan Feng , Jun-Dong Li , Jun Tang*, Xiao-Feng Zhu*. MAPK1/3 kinase-dependent ULK1 degradation attenuates mitophagy and promotes breast cancer bone metastasis. Autophagy 2021, 17(10):3011-3029.
  8. Yun Huang#, Hai-Liang Zhang#, Zhi-Ling Li#, Tian Du#, Yu-Hong Chen, Yan Wang, Huan-He Ni, Kai-Ming Zhang, Jia Mai, Bing-Xin Hu, Jun-Hao Huang, Li-Huan Zhou, Dong Yang, Xiao-Dan Peng, Gong-Kan Feng, Jun Tang*, Xiao-Feng Zhu*, and Rong Deng*. FUT8-mediated aberrant N-glycosylation of B7-H3 suppresses the immune response in triple-negative breast cancer. Nature Communications. 2021,12:2672  
  9. Hai-Liang Zhang, Yi-Qing Guo, Shan Liu, Zhi-Peng Ye, Li-Chao Li, Bing-Xin Hu, Zhi-Ling Li, Yu-Hong Chen, Gong-Kan Feng, Hui-Qi Shen, Rong Deng*, Xiao-Feng Zhu*. Galectin-13 reduces membrane localization of SLC7A11 for ferroptosis propagation. Nature Chemical Biology, 2025, 21(10):1531-1543.
  10.  Yan Yu#, Xiao-Dan Peng#, Xiao-Jun Qian#, Kai-Ming Zhang#, Xiang Huang, Yu-Hong Chen, Yun-Tian Li, Gong-Kan Feng, Hai-Liang Zhang, Xue-Lian Xu, Shun Li, Xuan Li, Jia Mai, Zhi-Ling Li, Yun Huang, Dong Yang, Li-Huan Zhou, Zhuo-Yan Zhong, Jun-Dong Li, Rong Deng* and Xiao-Feng Zhu*. Fis1 phosphorylation by Met promotes mitochondrial fission and hepatocellular carcinoma metastasis. Signal Transduction and Targeted Therapy 2021, 6(1):401.