临床专家

孙鹏

职务：病理科副主任、病理科师生党支部书记
职称：医学博士、主任医师、硕士/博士研究生导师

专长

乳腺肿瘤病理诊断、新型分子标志物研发及病理人工智能转化应用

中国抗癌协会病理专业委员会乳腺学组，副组长

中国老年保健协会乳腺癌专业委员会，常委

中国医药卫生事业发展基金会乳腺肿瘤学组，常委

广东省中西医结合学会病理学专业委员会，副主任委员

广东省保健协会乳腺肿瘤防治与康复分会，副主任委员

广东省卫生信息网络协会智慧乳腺癌分会，副会长

广东省医师协会病理科医师分会青年专业组，副组长

广东省抗癌协会肿瘤病理专业委员会，常委

第十六届中国病理医师年会“杰出青年病理医师”

以第一/通讯作者在PNAS, Adv Sci, Cancer Commun, EBioMedicine, Cancer Lett等发表论文

主持国家自然科学基金面上项目、广东省自然科学基金面上项目等科研项目

教育经历：

  1. 2005/09-2010/06，中山大学，临床医学，学士。
  2. 2010/09–2015/06，中山大学，病理学与病理生理学，博士。

工作经历：

  1. 2015/08-2018/12，中山大学肿瘤防治中心，病理科，医师。
  2. 2019/01–2020/12，中山大学肿瘤防治中心，病理科，主治医师。
  3. 2021/01–2025/12，中山大学肿瘤防治中心，病理科，副主任医师。
  4. 2026/01-至今，中山大学肿瘤防治中心，病理科，主任医师。

部分代表性论文（#为第一作者；*为通讯作者）

  1. Sun S(#), Hu H, Chen L, Gao Y, Sun P(*), Chen L(*). Ammonia Detoxification Inhibits Liver Metastasis by Reshaping Hepatic Microenvironment. Adv Sci (Weinh). 2026;13(33):e21098. 
  2. Zhang L(#), Zhou L(#), Yang A(#), Zheng S, Chen K, Zou Y, Zhou Q, Wang D, Xu F, Huang J, Yuan Z, Wang S, Shi Y, Sun P(*), An X(*). HER2-positive breast cancer with invasive micropapillary carcinoma component shows immunosuppressive microenvironment and resistance to neoadjuvant therapy. Front Immunol. 2025 Aug 1;16:1623675.
  3. Cai X(#), Chen Y(#), Li Q, Wei T, Yang Y, Ye R, Chao X, Li M, He J, Luo R, Xu S(*), Sun P(*). Prognostic value of tumor-infiltrating lymphocytes (TILs) in Luminal breast cancer: A novel computational method for assessing TILs abundance and spatial distribution patterns. Breast. 2025;84:104634.
  4. Jiang C(#), Li M(#), Zheng C(#), Yan S , Kong L, Wu Y, Zhang J, Chao X, Cai X, Feng W, He J, Luo R, Xu S(*), Yang Y(*), Sun P(*). Systematic Analysis of Factors Affecting Human Epidermal Growth Factor Receptor 2 Interpretation Consistency: Staining Protocols, Artificial Intelligence–Based Image Standardization, and Classification Criteria. Laboratory Investigation. 2025;105(6):104134. 
  5. Lu Q(#), Wang N(#), Jiang K(#), Zhou H, Zhang P, Zhang J, Wang S, Sun P(*), Xu F(*). Comprehensive genomic profiling to identify actionable alterations for breast cancer brain metastases in the Chinese population. ESMO Open. 2024;9(3):102389.
  6. Wu Y(#), Chen F(#), Pan L(#), Chao X, Li M, Luo R, Chen K, Zheng C, Du T(*), He J(*), Sun P(*). Diagnostic utility and sensitivities of matrix Gla protein (MGP), TRPS1 and GATA3 in breast cancer: focusing on metastatic breast cancer, invasive breast carcinoma with special features, and salivary gland-type tumours. Pathology. 2024;56(4):516-527. 
  7. Lu Q(#), Zhou H(#), Zhang J(#), Lee K, Chen L, Hong R, Jiang K, Xu F, Xia W, Cao B, Zhang J, Shao K, Sun P(*), Wang S(*). Clinicopathological characteristics and genomic profiling of pure mucinous breast cancer. Breast. 2024.
  8. Chao X(#), Zhang Y(#), Zheng C, Huang Q, Lu J, Pulver EM, Houthuijzen J, Hutten S, Luo R, He J, Sun P(*). Metastasis of breast cancer to bones alters the tumor immune microenvironment. Eur J Med Res. 2023;28(1):119. 
  9. Wang L(#), Sun P(#), Xu F, Zheng Q, Jiang K, Hong R(*), Wang S(*). Construction of immune score and its prognostic value in invasive lobular carcinoma of the breast using computational pathology analysis. Cancer Med. 2023;13(1):e6896. 
  10. Du T(#), Pan L(#), Zheng C(#), Chen K, Yang Y, Chen J, Chao X, Li M, Lu J, Luo R, Zhang J, Wu Y, He J(*), Jiang D(*), Sun P(*). Matrix Gla protein (MGP), GATA3, and TRPS1: a novel diagnostic panel to determine breast origin. Breast Cancer Res. 2022;24(1):70.
  11. Liu W(#), Sun P(#), Xia L, He X, Xia Z, Huang Y, Liu W, Li L, Chen L(*). A brain-enriched lncRNA shields cancer cells from immune-mediated killing for metastatic colonization in the brain. Proc Natl Acad Sci U S A. 2022;119(22): e2200230119. 
  12. Sun P(#)(*), He J(#), Chao X(#), Chen K, Xu Y, Huang Q, Yun J, Li M, Luo R, Kuang J, Wang H, Li H, Hui H, Xu S(*). A computational tumor-infiltrating lymphocyte assessment method comparable with visual reporting guidelines for triple-negative breast cancer. EBioMedicine. 2021;70:103492.
  13. Zhang N(#), Sun P(#), Xu Y, Li H, Liu H, Wang L, Cao Y, Zhou K(*), Wang T(*). The GPER1/SPOP axis mediates ubiquitination-dependent degradation of ERα to inhibit the growth of breast cancer induced by oestrogen. Cancer Lett. 2021;498:54-69.
  14. Chao X(#), Tan W(#), Tsang JY, Tse GM, Hu J, Li P, Hou J, Li M, He J(*), Sun P(*). Clinicopathologic and genetic features of metaplastic breast cancer with osseous differentiation: a series of 6 cases. Breast Cancer. 2021;28(5):1100-1111. 
  15. Sun P(#)(*), Zhong Z(#), Lu Q(#), Li M, Chao X, Chen D, Hu W, Luo R, He J(*). Mucinous carcinoma with micropapillary features is morphologically, clinically and genetically distinct from pure mucinous carcinoma of breast. Mod Pathol. 2020;33(10):1945-1960.
  16. Xu Y(#), Ye S(#), Zhang N, Zheng S, Liu H, Zhou K, Wang L, Cao Y, Sun P(*), Wang T(*). The FTO/miR-181b-3p/ARL5B signaling pathway regulates cell migration and invasion in breast cancer. Cancer Commun (Lond). 2020;40(10):484-500. 

 

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中国抗癌协会病理专业委员会乳腺学组，副组长

中国老年保健协会乳腺癌专业委员会，常委

中国医药卫生事业发展基金会乳腺肿瘤学组，常委

广东省中西医结合学会病理学专业委员会，副主任委员

广东省保健协会乳腺肿瘤防治与康复分会，副主任委员

广东省卫生信息网络协会智慧乳腺癌分会，副会长

广东省医师协会病理科医师分会青年专业组，副组长

广东省抗癌协会肿瘤病理专业委员会，常委

第十六届中国病理医师年会“杰出青年病理医师”

以第一/通讯作者在PNAS, Adv Sci, Cancer Commun, EBioMedicine, Cancer Lett等发表论文

主持国家自然科学基金面上项目、广东省自然科学基金面上项目等科研项目

教育经历：

  1. 2005/09-2010/06，中山大学，临床医学，学士。
  2. 2010/09–2015/06，中山大学，病理学与病理生理学，博士。

工作经历：

  1. 2015/08-2018/12，中山大学肿瘤防治中心，病理科，医师。
  2. 2019/01–2020/12，中山大学肿瘤防治中心，病理科，主治医师。
  3. 2021/01–2025/12，中山大学肿瘤防治中心，病理科，副主任医师。
  4. 2026/01-至今，中山大学肿瘤防治中心，病理科，主任医师。

部分代表性论文（#为第一作者；*为通讯作者）

  1. Sun S(#), Hu H, Chen L, Gao Y, Sun P(*), Chen L(*). Ammonia Detoxification Inhibits Liver Metastasis by Reshaping Hepatic Microenvironment. Adv Sci (Weinh). 2026;13(33):e21098. 
  2. Zhang L(#), Zhou L(#), Yang A(#), Zheng S, Chen K, Zou Y, Zhou Q, Wang D, Xu F, Huang J, Yuan Z, Wang S, Shi Y, Sun P(*), An X(*). HER2-positive breast cancer with invasive micropapillary carcinoma component shows immunosuppressive microenvironment and resistance to neoadjuvant therapy. Front Immunol. 2025 Aug 1;16:1623675.
  3. Cai X(#), Chen Y(#), Li Q, Wei T, Yang Y, Ye R, Chao X, Li M, He J, Luo R, Xu S(*), Sun P(*). Prognostic value of tumor-infiltrating lymphocytes (TILs) in Luminal breast cancer: A novel computational method for assessing TILs abundance and spatial distribution patterns. Breast. 2025;84:104634.
  4. Jiang C(#), Li M(#), Zheng C(#), Yan S , Kong L, Wu Y, Zhang J, Chao X, Cai X, Feng W, He J, Luo R, Xu S(*), Yang Y(*), Sun P(*). Systematic Analysis of Factors Affecting Human Epidermal Growth Factor Receptor 2 Interpretation Consistency: Staining Protocols, Artificial Intelligence–Based Image Standardization, and Classification Criteria. Laboratory Investigation. 2025;105(6):104134. 
  5. Lu Q(#), Wang N(#), Jiang K(#), Zhou H, Zhang P, Zhang J, Wang S, Sun P(*), Xu F(*). Comprehensive genomic profiling to identify actionable alterations for breast cancer brain metastases in the Chinese population. ESMO Open. 2024;9(3):102389.
  6. Wu Y(#), Chen F(#), Pan L(#), Chao X, Li M, Luo R, Chen K, Zheng C, Du T(*), He J(*), Sun P(*). Diagnostic utility and sensitivities of matrix Gla protein (MGP), TRPS1 and GATA3 in breast cancer: focusing on metastatic breast cancer, invasive breast carcinoma with special features, and salivary gland-type tumours. Pathology. 2024;56(4):516-527. 
  7. Lu Q(#), Zhou H(#), Zhang J(#), Lee K, Chen L, Hong R, Jiang K, Xu F, Xia W, Cao B, Zhang J, Shao K, Sun P(*), Wang S(*). Clinicopathological characteristics and genomic profiling of pure mucinous breast cancer. Breast. 2024.
  8. Chao X(#), Zhang Y(#), Zheng C, Huang Q, Lu J, Pulver EM, Houthuijzen J, Hutten S, Luo R, He J, Sun P(*). Metastasis of breast cancer to bones alters the tumor immune microenvironment. Eur J Med Res. 2023;28(1):119. 
  9. Wang L(#), Sun P(#), Xu F, Zheng Q, Jiang K, Hong R(*), Wang S(*). Construction of immune score and its prognostic value in invasive lobular carcinoma of the breast using computational pathology analysis. Cancer Med. 2023;13(1):e6896. 
  10. Du T(#), Pan L(#), Zheng C(#), Chen K, Yang Y, Chen J, Chao X, Li M, Lu J, Luo R, Zhang J, Wu Y, He J(*), Jiang D(*), Sun P(*). Matrix Gla protein (MGP), GATA3, and TRPS1: a novel diagnostic panel to determine breast origin. Breast Cancer Res. 2022;24(1):70.
  11. Liu W(#), Sun P(#), Xia L, He X, Xia Z, Huang Y, Liu W, Li L, Chen L(*). A brain-enriched lncRNA shields cancer cells from immune-mediated killing for metastatic colonization in the brain. Proc Natl Acad Sci U S A. 2022;119(22): e2200230119. 
  12. Sun P(#)(*), He J(#), Chao X(#), Chen K, Xu Y, Huang Q, Yun J, Li M, Luo R, Kuang J, Wang H, Li H, Hui H, Xu S(*). A computational tumor-infiltrating lymphocyte assessment method comparable with visual reporting guidelines for triple-negative breast cancer. EBioMedicine. 2021;70:103492.
  13. Zhang N(#), Sun P(#), Xu Y, Li H, Liu H, Wang L, Cao Y, Zhou K(*), Wang T(*). The GPER1/SPOP axis mediates ubiquitination-dependent degradation of ERα to inhibit the growth of breast cancer induced by oestrogen. Cancer Lett. 2021;498:54-69.
  14. Chao X(#), Tan W(#), Tsang JY, Tse GM, Hu J, Li P, Hou J, Li M, He J(*), Sun P(*). Clinicopathologic and genetic features of metaplastic breast cancer with osseous differentiation: a series of 6 cases. Breast Cancer. 2021;28(5):1100-1111. 
  15. Sun P(#)(*), Zhong Z(#), Lu Q(#), Li M, Chao X, Chen D, Hu W, Luo R, He J(*). Mucinous carcinoma with micropapillary features is morphologically, clinically and genetically distinct from pure mucinous carcinoma of breast. Mod Pathol. 2020;33(10):1945-1960.
  16. Xu Y(#), Ye S(#), Zhang N, Zheng S, Liu H, Zhou K, Wang L, Cao Y, Sun P(*), Wang T(*). The FTO/miR-181b-3p/ARL5B signaling pathway regulates cell migration and invasion in breast cancer. Cancer Commun (Lond). 2020;40(10):484-500.