朱孝峰

朱孝峰，中山大学肿瘤防治中心二级研究员，博士生导师，华南恶性肿瘤防治全国重点实验室副主任，实验研究部主任，广东省“特支计划”百千万工程领军人才，教育部新世纪优秀人才。主要从事肿瘤细胞死亡调控、免疫逃逸与靶向药物研究。2000年在美国乔治城大学癌症中心学习。现为中国抗癌协会抗癌药物专业委员会副主任委员、中国药理学会肿瘤药理专业委员会副主任委员、肿瘤精准治疗专业委员会常委、肿瘤代谢专业委员会常委，广东省抗癌协会抗肿瘤药物专业委员会主任委员，《Cancer Communications》、《Advances in Therapy》等杂志编委。已获主持国家自然科学基金重点项目（2项）、面上项目（7项），国家重点研发计划等多项课题。主编人民卫生出版社出版的《信号转导与疾病》和广东科技出版社出版的《肿瘤生物治疗学》专著二部。申请专利九项，五项发明专利已获授权。

近5年代表性论著 （* 通讯作者）

1. Hai-Liang Zhang, Bing-Xin Hu, Zhi-Ling Li, Tian Du, Jia-Lu Shan, Zhi-Peng Ye, Xiao-Dan Peng, Xuan Li, Yun Huang, Xian-Ying Zhu, Yu-Hong Chen, Gong-Kan Feng, Dajun Yang, Rong Deng*, Xiao-Feng Zhu*. PKCβII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis. Nature Cell Biology, 2022, 24(1):88-98.

2. Hai-Liang Zhang, Yi-Qing Guo, Shan Liu, Zhi-Peng Ye, Li-Chao Li, Bing-Xin Hu, Zhi-Ling Li, Yu-Hong Chen, Gong-Kan Feng, Hui-Qi Shen, Rong Deng*, Xiao-Feng Zhu*. Galectin-13 reduces membrane localization of SLC7A11 for ferroptosis propagation. Nature Chemical Biology, 2025, 21(10):1531-1543.

3. Hai-Liang Zhang, Bing-Xin Hu, Zhi-Peng Ye, Zhi-Ling Li, Shan Liu, Wen-Qing Zhong, Tian Du, Dong Yang, Jia Mai, Li-Chao Li, Yu-Hong Chen, Xian-Ying Zhu, Xuan Li, Gong-Kan Feng, Xiao-Feng Zhu*, Rong Deng*. TRPML1 triggers ferroptosis defense and is a potential therapeutic target in AKT-hyperactivated cancer. Science Translational Medicine, 2024, 16(753):eadk0330.

4. Li-Chao Li, Zhi-Peng Ye, Ying Xiao, Xian-Ying Zhu, Qia-Qia Li, Yi-Qing Guo, Huai-Liang Wu, Zhi-Ling Li, Lin-Yu Wu, Yu-Hong Chen, Gong-Kan Feng, Dong Yang, Shan Liu, Bing-Xin Hu, Jia-Hong Tang, Yu-Feng Zhou, Jing Li, Rong Deng*, Hai-Liang Zhang*, Xiao-Feng Zhu*. AAK1 activation-mediated iron trafficking drives ferroptotic cell death. Nature Communications‌, 2025, 17(1):819.

5. Yan Yu, Xiao-Dan Peng, Xiao-Jun Qian, Kai-Ming Zhang, Xiang Huang, Yu-Hong Chen, Yun-Tian Li, Gong-Kan Feng, Hai-Liang Zhang, Xue-Lian Xu, Shun Li, Xuan Li, Jia Mai, Zhi-Ling Li, Yun Huang, Dong Yang, Li-Huan Zhou, Zhuo-Yan Zhong, Jun-Dong Li, Rong Deng*, Xiao-Feng Zhu*. Fis1 phosphorylation by Met promotes mitochondrial fission and hepatocellular carcinoma metastasis. Signal Transduction and Targeted Therapy, 2021, 6(1):401.

6. Jia-Lu Shan, Kai-Ming Zhang, Wen-Qing Zhong, Xiao-Yu Yang, Zhi-Ling Li, Yun Huang, Tian Du, Dong Yang, Jia-Hong Tang, Yu-Hong Chen, Hai-Liang Zhang, Xiao-Feng Zhu*, Rong Deng*. Reactivating cGAS-STING Signaling by Targeting SOS1 Enhances Antitumor Immunity in NRAS-Mutant Tumors. Cancer Research, 2025, 85(16):3015-3031. 

7. Yun Huang, Wen-Qing Zhong, Xiao-Yu Yang, Jia-Lu Shan, Ling Zhou, Zhi-Ling Li, Yi-Qing Guo, Kai-Ming Zhang, Tian Du, Hai-Liang Zhang, Bing-Xin Hu, Yu-Hong Chen, Dong Yang, Gong-Kan Feng, Jun Tang*, Xiao-Feng Zhu*, Rong Deng*. Targeting site-specific N-glycosylated B7H3 induces potent antitumor immunity. Nature Communications, 2025, 16(1):3546.

8. Xuan Li, Kai-Bin Yang, Wei Chen, Jia Mai, Xiao-Qi Wu, Ting Sun, Rui-Yan Wu, Lin Jiao, Dan-Dan Li, Jiao Ji, Hai-Liang Zhang, Yan Yu, Yu-Hong Chen, Gong-Kan Feng, Rong Deng, Jun-Dong Li*, Xiao-Feng Zhu*. CUL3 (cullin 3)-mediated ubiquitination and degradation of BECN1 (beclin 1) inhibit autophagy and promote tumor progression. Autophagy, 2021 Dec;17(12):4323-4340.

9. Rong Deng, Hai-Liang Zhang, Jun-Hao Huang, Rui-Zhao Cai, Yan Wang ,Yu-Hong Chen , Bing-Xin Hu, Zhi-Peng Ye, Zhi-Ling Li, Jia Mai, Yun Huang, Xuan Li, Xiao-Dan Peng, Gong-Kan Feng, Jun-Dong Li, Jun Tang*, Xiao-Feng Zhu*. MAPK1/3 kinase dependent ULK1 degradation attenuates mitophagy and promotes breast cancer bone metastasis. Autophagy, 2021, 17(10):3011-3029.

10. Yun Huang, Hai-Liang Zhang, Zhi-Ling Li, Tian Du, Yu-Hong Chen, Yan Wang, Huan-He Ni, Kai-Ming Zhang, Jia Mai, Bing-Xin Hu, Jun-Hao Huang, Li-Huan Zhou, Dong Yang, Xiao-Dan Peng, Gong-Kan Feng, Jun Tang*, Xiao-Feng Zhu*, Rong Deng*. FUT8-mediated aberrant N-glycosylation of B7H3 suppresses the immune response in triple-negative breast cancer. Nature Communications, 2021, 12(1):2672.

11. Zhi-Ling Li, Hai-Liang Zhang, Yun Huang, Jun-Hao Huang, Peng Sun, Ning-Ning Zhou,Yu-Hong Chen, Jia Mai, Yan Wang, Yan Yu, Li-Huan Zhou, Xuan Li, Dong Yang, Xiao-Dan Peng,Gong-Kan Feng, Jun Tang*, Xiao-Feng Zhu*, Rong Deng*. Autophagy deficiency promotes triple-negative breast cancer resistance to T cell-mediated cytotoxicity by blocking tenascin-C degradation. Nature Communications, 2020, 11(1):3806.

12. Rui-Yan Wu, Caiq-Qin Wang, Zhi-Ming Li, Jian Xiao, Chun-Yan Li, Xue-Min Wang, Peng-Fei Kong, Jiang-Hua Cao, Fu-Xue Huang, Zhi-Ling Li, Yun Huang, Yu-Hong Chen, Xuan Li, Dong Yang, Hai-Liang Zhang, Jia Mai, Gong-Kan Feng, Rong Deng*, Xiaofeng Zhu*. SOX2 promotes resistance of melanoma with PD-L1 high expression to T-cell mediated cytotoxicity that can be reversed by SAHA. Journal for ImmunoTherapy of Cancer, 2020, 8:e001037.